Tail Length and E525K Dilated Cardiomyopathy Mutant Alter Human β-Cardiac Myosin Super-Relaxed State.
Sebastian Duno-MirandaShane R NelsonDavid V RasicciSkylar L M BodtJoseph A CiriloDuha VangSivaraj SivaramakrishnanChristopher M YengoDavid M WarshawPublished in: bioRxiv : the preprint server for biology (2023)
This research investigates the E525K mutation in human β-cardiac myosin, crucial for heart contraction, and its role in causing Dilated Cardiomyopathy (DCM). It demonstrates that the length of the myosin tail influences its self-inhibition, and the E525K mutation strengthens this effect, potentially reducing heart contractility in DCM.