Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.
Matthias HeinigMichiel E AdriaensSebastian SchaferHanneke W M van DeutekomElisabeth M LodderJames S WareValentin SchneiderLeanne E FelkinEsther E CreemersBenjamin MederHugo A KatusFrank RühleMonika StollFrançois CambienEric VillardPhilippe CharronAndras VarroNanette H BishopricAlfred L GeorgeCristobal Dos RemediosAida Moreno-MoralFrancesco PesceAnja BauerfeindFranz RüschendorfCarola RintischEnrico PetrettoPaul J BartonStuart A CookYigal M PintoConnie R BezzinaNorbert HubnerPublished in: Genome biology (2017)
RNA transcription, splicing, and allele-specific expression are each important determinants of the dilated cardiomyopathy phenotype and are controlled by genetic factors. Our results represent a powerful resource for the field of cardiovascular genetics.