Versiquinazolines L-Q, new polycyclic alkaloids from the marine-derived fungus Aspergillus versicolor .
Zhongbin ChengDong LiuWei ChengPeter ProkschWen-Han LinPublished in: RSC advances (2018)
Further chemical examination of a coral-associated fungus Aspergillus versicolor LZD-14-1 by the PHLC-DAD detection resulted in the isolation of six new polycyclic alkaloids, namely versiquinazolines L-Q (1-6). Their structures were determined by extensive analyses of spectroscopic data, including quantum ECD calculation and X-ray single crystal diffraction for the assignment of absolute configurations. Versiquinazoline L bearing a d-Ala residue and versiquinazoline M containing an l-serine residue are rarely found in the fumiquinazoline-type alkaloids, while versiquinazoline P displayed an unusual scaffold with a spiro-γ-lactone. Versiquinazolines P and Q exhibited significant inhibition against thioredoxin reductase (TrxR) with IC 50 values of 13.6 ± 0.6 and 12.2 ± 0.7 μM, which showed higher activity than the positive control curcumin (IC 50 = 25 μM). The weak cytotoxicity and potent inhibition toward TrxR suggested that versiquinazolines P and Q are potential for microenvironmental regulation of tumor progression and metastasis.
Keyphrases
- high resolution
- ms ms
- poor prognosis
- molecular docking
- electronic health record
- molecular dynamics
- electron microscopy
- big data
- amino acid
- monte carlo
- simultaneous determination
- magnetic resonance
- magnetic resonance imaging
- label free
- risk assessment
- long non coding rna
- protein kinase
- computed tomography
- human health
- real time pcr
- climate change
- solid state