AUTOPSY STUDY OF TESTICLES IN COVID-19: UPREGULATION OF IMMUNE-RELATED GENES AND DOWNREGULATION OF TESTIS-SPECIFIC GENES.
Alessio BasoloAnello Marcello PomaElisabetta MacerolaDiana BonuccelliAgnese ProiettiAlessandra SalvettiPaola VignaliLiborio TorregrossaLaura EvangelistiRebecca SparavelliRiccardo GianniniClara UgoliniFulvio BasoloFerruccio SantiniAntonio TonioloPublished in: The Journal of clinical endocrinology and metabolism (2022)
In lethal COVID-19 cases, infection of testicular cells is not uncommon. Viral infection associates with activation of interferon pathways and downregulation of testis-specific genes involved in spermatogenesis. Due to the exceedingly high numbers of infected people in the pandemic, the impact of virus on fertility should be further investigated.
Keyphrases
- coronavirus disease
- sars cov
- cell proliferation
- signaling pathway
- induced apoptosis
- germ cell
- respiratory syndrome coronavirus
- cell cycle arrest
- genome wide
- poor prognosis
- oxidative stress
- pi k akt
- young adults
- gene expression
- immune response
- mass spectrometry
- bioinformatics analysis
- single molecule
- childhood cancer
- disease virus