Tyrosinase-Treated Hydroxytyrosol-Enriched Olive Vegetation Waste with Increased Antioxidant Activity Promotes Autophagy and Inhibits the Inflammatory Response in Human THP-1 Monocytes.
Roberta MeschiniDonatella D'EliseoSilvia FilippiLaura BertiniBruno Mattia BizzarriLorenzo BottaRaffaele SaladinoFrancesca VelottiPublished in: Journal of agricultural and food chemistry (2018)
Treatment of olive vegetation waste with tyrosinase immobilized on multiwalled carbon nanotubes increased the antioxidant activity as a consequence of the conversion of phenols to corresponding catechol derivatives, as evaluated by DPPH, Comet assay, and micronucleus analyses. During this transformation, 4-hydroxyphenethyl alcohol (tyrosol) was quantitatively converted to bioactive 3,4-dihydroxyphenethyl alcohol (hydroxytyrosol). The hydroxytyrosol-enriched olive vegetation waste also promoted autophagy and inhibited the inflammatory response in human THP-1 monocytes.
Keyphrases
- inflammatory response
- endothelial cells
- climate change
- carbon nanotubes
- heavy metals
- cell death
- lipopolysaccharide induced
- endoplasmic reticulum stress
- signaling pathway
- sewage sludge
- oxidative stress
- induced pluripotent stem cells
- dendritic cells
- pluripotent stem cells
- lps induced
- municipal solid waste
- peripheral blood
- high throughput
- alcohol consumption
- risk assessment
- newly diagnosed