Malaria and tuberculosis as diseases of neglected populations: state of the art in chemotherapy and advances in the search for new drugs.
Renan Vinicius de AraújoSoraya Silva SantosLuccas Missfeldt SanchesJeanine GiarollaOmar El SeoudElizabeth Igne FerreiraPublished in: Memorias do Instituto Oswaldo Cruz (2020)
Malaria and tuberculosis are no longer considered to be neglected diseases by the World Health Organization. However, both are huge challenges and public health problems in the world, which affect poor people, today referred to as neglected populations. In addition, malaria and tuberculosis present the same difficulties regarding the treatment, such as toxicity and the microbial resistance. The increase of Plasmodium resistance to the available drugs along with the insurgence of multidrug- and particularly tuberculosis drug-resistant strains are enough to justify efforts towards the development of novel medicines for both diseases. This literature review provides an overview of the state of the art of antimalarial and antituberculosis chemotherapies, emphasising novel drugs introduced in the pharmaceutical market and the advances in research of new candidates for these diseases, and including some aspects of their mechanism/sites of action.
Keyphrases
- drug resistant
- plasmodium falciparum
- mycobacterium tuberculosis
- public health
- pulmonary tuberculosis
- multidrug resistant
- hiv aids
- acinetobacter baumannii
- escherichia coli
- mental health
- adverse drug
- oxidative stress
- microbial community
- squamous cell carcinoma
- case report
- health insurance
- human immunodeficiency virus
- global health
- genetic diversity
- smoking cessation