Paeoniflorin Regulates NEDD4L/STAT3 Pathway to Induce Ferroptosis in Human Glioma Cells.

Xiao-Hu Nie Xiaochun Ji Ying Xing Jie Xu Bin Lu Shu-Fa Zhao Yun-Tao Li Zhong-Zhou Su

Published in: Journal of oncology (2022)

In summary, this study demonstrated that paeoniflorin might function as an effective drug for glioma by inducing ferroptosis via upregulation of NEDD4L and repression of Nrl2, GPX4, and STAT3.

Keyphrases

cell proliferation
cell death
endothelial cells
poor prognosis
signaling pathway
emergency department
drug induced
long non coding rna