Cumulative pulse methylprednisolone and its relation to disease activity, damage and mortality in systemic lupus erythematosus patients: A post hoc analysis of COMOSLE-EGYPT study.
Nesreen SobhyYasser EzzatSherif M GamalShada A GhoniemSarah S NasrShaimaa BadranAhmed SolimanNermeen Ahmed FouadPublished in: Clinical rheumatology (2024)
With every gram increase in the cumulative methylprednisolone, there may be increase in damage and mortality, especially in doses exceeding the range of 2.75-3.25 g. Key Points • Treatment of systemic lupus erythematosus should be with the least possible dose of steroids to decrease the risk of damage and mortality. • With every gram increase in the cumulative intravenous methylprednisolone there may be increase in damage and mortality.
Keyphrases
- systemic lupus erythematosus
- disease activity
- cardiovascular events
- high dose
- oxidative stress
- rheumatoid arthritis
- risk factors
- end stage renal disease
- ankylosing spondylitis
- gram negative
- rheumatoid arthritis patients
- ejection fraction
- newly diagnosed
- chronic kidney disease
- type diabetes
- juvenile idiopathic arthritis
- low dose
- blood pressure
- cardiovascular disease
- multidrug resistant
- patient reported