Presence of a 34-gene signature is a favorable prognostic marker in squamous non-small cell lung carcinoma.
Willemijn S M E TheelenO KrijgsmanK MonkhorstT KuilmanD D G C PetersS CornelissenM A LigtenbergS M WillemsJ L G BlaauwgeersC J M van NoeselD S PeeperM M van den HeuvelK SchulzePublished in: Journal of translational medicine (2020)
These findings suggest that the ability of immune cell infiltration and the interaction between tumor and immune cells may be different between AD and SCC histology and that a subgroup of SCC tumors seems more susceptible to Natural Killer cell recognition and killing, whereas this may not occur in AD tumors. A highly sensitive technique like NanoString was able to detect this subgroup based on a 34-gene signature, but further research will be needed to assist in explaining the biological rationale of such low-level expression signatures.