Electrocardiogram-less, free-breathing myocardial extracellular volume fraction mapping in small animals at high heart rates using motion-resolved cardiovascular magnetic reesonance multitasking: a feasibility study in a heart failure with preserved ejection fraction rat model.
Pei HanRui ZhangShawn WagnerYibin XieEugenio CingolaniEduardo MarbanAnthony G ChristodoulouDebiao LiPublished in: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance (2021)
Motion-resolved ECV Multitasking CMR can quantify ECV in the rat myocardium at high heart rates without ECG triggering or respiratory gating. Elevated ECV found in the HFpEF group is consistent with previous human studies and well correlated with histological data. This technique has the potential to be a viable imaging tool for myocardial tissue characterization in small animal models.
Keyphrases
- high resolution
- left ventricular
- heart failure
- endothelial cells
- high speed
- atrial fibrillation
- oxidative stress
- electronic health record
- heart rate variability
- heart rate
- blood pressure
- big data
- molecularly imprinted
- machine learning
- pluripotent stem cells
- high density
- mass spectrometry
- human health
- photodynamic therapy
- solid phase extraction