Reconstruction of intraoral oncologic surgical defects with Integra® bilayer wound matrix.
Akanksha SrivastavaAnastasios ManiakasJeffrey N MyersMark S ChambersRichard C CardosoPublished in: Clinical case reports (2020)
Utilization of biologic skin substitutes for the management of soft tissue defects as an alternative to autologous skin grafts has expanded over the past 2 decades. The purpose of this case series study was to report our experience with Integra® bilayer wound matrix for reconstruction of intraoral oncologic defects. Case records of 6 patients with intraoral oncologic defects reconstructed with Integra® bilayer wound matrix were retrospectively reviewed. The surgical defect location, size, and time to removal of surgical splint varied. Clinically, normal oral epithelialization was noted for all patients. One patient demonstrated a small area of dehiscence and bone exposure after adjuvant radiation therapy which resolved with minimal intervention. Integra bilayer wound matrix is a viable and versatile option for reconstruction of intraoral oncologic surgical defects. Further exploration of wound healing with Integra® matrix, surgical techniques, and cost-effectiveness is advocated.
Keyphrases
- wound healing
- soft tissue
- radiation therapy
- rectal cancer
- radical prostatectomy
- randomized controlled trial
- robot assisted
- rheumatoid arthritis
- prostate cancer
- ejection fraction
- newly diagnosed
- early stage
- stem cells
- squamous cell carcinoma
- case report
- bone mineral density
- body composition
- postmenopausal women
- mesenchymal stem cells
- patient reported outcomes
- locally advanced
- bone loss