Increase of CD4+CD25highFoxP3+ cells impairs in vitro human microbicidal activity against Mycobacterium tuberculosis during latent and acute pulmonary tuberculosis.

Lorenzzo Lyrio Stringari Luciana Polaco Covre Flávia Dias Coelho da Silva Vivian Leite de OliveiraMaria Carolina CampanaDavid Jamil HadadMoisés PalaciPadmini SalgameReynaldo Dietze Daniel Cláudio de Oliveira Gomes Rodrigo Ribeiro-Rodrigues

Published in: PLoS neglected tropical diseases (2021)

Tregs restrict host anti-mycobacterial immunity during active disease and latent infection and thereby may contribute to both disease progression and pathogen persistence.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
induced apoptosis
endothelial cells
liver failure
cell cycle arrest
respiratory failure
induced pluripotent stem cells
drug induced
pluripotent stem cells
aortic dissection
oxidative stress
cell death
intensive care unit
hepatitis b virus
pi k akt