Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning.

Mark C YaremaPuja ChopraMarco L A SivilottiDavid JohnsonAlberto Nettel-AguirreBenoit BaileyCharlemaigne VictorinoSophie GosselinRoy PurssellMargaret ThompsonDaniel SpykerBarry Rumack

Published in: Journal of medical toxicology : official journal of the American College of Medical Toxicology (2018)

Anaphylactoid reactions to the 21-h IV NAC protocol were uncommon and involved primarily cutaneous symptoms. While the protective effects of higher APAP concentrations are of interest in understanding the pathophysiology, none of the associations identified are strong enough to substantially alter the threshold for NAC initiation.

Keyphrases

transcription factor
randomized controlled trial
high dose
genome wide analysis
liver injury
sleep quality
physical activity