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Robust normalization and transformation techniques for constructing gene coexpression networks from RNA-seq data.

Kayla A JohnsonArjun Krishnan
Published in: Genome biology (2022)
Based on this work, we provide concrete recommendations on robust procedures for building an accurate coexpression network from an RNA-seq dataset. In addition, researchers can examine all the results in great detail at https://krishnanlab.github.io/RNAseq_coexpression to make appropriate choices for coexpression analysis based on the experimental factors of their RNA-seq dataset.
Keyphrases
  • rna seq
  • network analysis
  • single cell
  • genome wide
  • copy number
  • high resolution
  • electronic health record
  • gene expression
  • machine learning
  • dna methylation
  • deep learning
  • genome wide identification