Inflammation and acute cardiotoxicity in adult hematological patients treated with CAR-T cells: results from a pilot proof-of-concept study.

Massimiliano CamilliMarcello ViscovoTamara FeliciLuca MaggioFederico BallacciGiacomo CarellaAlice BonanniPriscilla LamendolaLorenzo TintiAntonio Di RenzoGiulia CoarelliEugenio GalliGiovanna LiuzzoFrancesco BurzottaRocco Antonio MontoneFederica SoràSimona SicaStefan HohausGaetano Antonio LanzaFilippo CreaAntonella LombardoGiorgio Minotti

Published in: Cardio-oncology (London, England) (2024)

There is a high incidence of early CTRCD in patients treated with CAR-T cells, and a link between CTRCD and inflammation can be demonstrated. Dedicated patient monitoring protocols are advised.

Keyphrases

oxidative stress
induced apoptosis
liver failure
cell cycle arrest
case report
study protocol
randomized controlled trial
drug induced
endoplasmic reticulum stress
aortic dissection
clinical trial
cell proliferation