Use of selected samples to diagnose a tricky feline viral disease in a cat with uveitis and neurological signs.
Julio Cesar Neves de AlmeidaHeloísa Cristina Teixeira de CarvalhoLana Isabella GilaNathana Beatriz MartinsMatias Pablo Juan SzabóAline Santana da HoraPublished in: Brazilian journal of veterinary medicine (2023)
This case involved a 2-year-old neutered male domestic mixed-breed cat that was rescued from the street eight months earlier. The animal presented with weakness, hyporexia, progressive weight loss, fatigue, uveitis, pale mucous membranes, dehydration (7%), and pelvic limb paresis. Aqueous humor was collected for molecular analysis for the differential diagnosis of potential etiological agents [Feline coronavirus (FCoV), Feline leukemia virus (FeLV), Feline immunodeficiency virus (FIV), Toxoplasma gondii , Cryptococcus spp., Felid herpesvirus -1 (FHV-1) and Bartonella spp.] of feline uveitis. The sample was positive by real-time reverse transcription-polymerase chain reaction (RT-qPCR) for FCoV and RT-qPCR and real-time polymerase chain reaction (qPCR) for FeLV and qPCR FIV. The cat was euthanized due to poor clinical outcomes and prognosis. A cerebrospinal fluid (CSF) sample was collected and tested, and the same pathogens were found in the aqueous humor. Small-cell follicular multicenter lymphoma and multifocal pyogranulomatous meningoencephalitis were observed upon histopathological analysis. In this study, aqueous humor and cerebrospinal fluid samples were efficient for the detection of coinfection with FIV, FeLV, and FCoV.
Keyphrases
- cerebrospinal fluid
- juvenile idiopathic arthritis
- toxoplasma gondii
- ankylosing spondylitis
- weight loss
- sars cov
- ionic liquid
- multiple sclerosis
- acute myeloid leukemia
- bone marrow
- diffuse large b cell lymphoma
- type diabetes
- transcription factor
- single cell
- rheumatoid arthritis
- risk assessment
- cross sectional
- disease activity
- adipose tissue
- gram negative
- skeletal muscle
- coronavirus disease
- real time pcr
- multidrug resistant
- brain injury
- weight gain
- antimicrobial resistance
- obese patients
- glycemic control
- disease virus