Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization.

Carmelo PugliaDebora SantonocitoAngela BonaccorsoTeresa MusumeciBarbara Ruozi Rosario Pignatello Claudia CarboneCarmela ParentiSantina Chiechio

Published in: Pharmaceutics (2020)

Drug encapsulation in lipid nanoparticles produced an optimization of CPS release, thus reducing mice pain behavior and avoiding the effects that are caused by TRPV1 defunctionalization related to a prolonged activation of this receptor.

Keyphrases

neuropathic pain
drug induced
chronic pain
fatty acid
high glucose
pain management
diabetic rats
spinal cord injury
spinal cord
high fat diet induced
endothelial cells
mouse model
adverse drug
iron oxide
binding protein
skeletal muscle
wild type
electronic health record
stress induced