Secreted protein profiling of human aortic smooth muscle cells identifies vascular disease associations.

Rédouane AherrahrouFerheen BaigKonstantinos TheofilatosDillon LueAlicia BeeleTiit ÖrdMinna U KaikkonenZouhair AherrahrouQi ChengSaikat GhoshSantosh KarnewarVaishnavi KarnewarAloke FinnGary K OwensMichael JonerManuel MayrMete Civelek

Published in: medRxiv : the preprint server for health sciences (2023)

Our results unravel the SMC proteome signature associated with vascular disorders, which may help identify potential therapeutic targets to accelerate the pathway to translation.

Keyphrases

coronary artery
pulmonary artery
endothelial cells
genome wide
aortic valve
left ventricular
induced pluripotent stem cells
single cell
pluripotent stem cells
gene expression
binding protein
atrial fibrillation
pulmonary arterial hypertension