Login / Signup

A unique sarcopenic progression in the mouse rotator cuff.

Gretchen A MeyerKaren C Shen
Published in: Journal of cachexia, sarcopenia and muscle (2021)
These data indicate that female mice replicate the unique sarcopenic pathology in the ageing human RC. Furthermore, they suggest that the exacerbated fatty infiltration is due to an interaction between higher resident fibro-adipogenic progenitor numbers and an elevated systemic inflammation in aged female mice. We conclude that female mouse RC muscle is a novel system to study both human RC degeneration and the signals that regulate sarcopenic fatty infiltration in general, which is prevalent in humans but largely absent from the rodent hindlimb.
Keyphrases
  • endothelial cells
  • rotator cuff
  • induced pluripotent stem cells
  • high fat diet induced
  • skeletal muscle
  • type diabetes
  • electronic health record
  • fatty acid
  • metabolic syndrome
  • quality improvement