Synthetic genetic circuits to uncover and enforce the OCT4 trajectories of successful reprogramming of human fibroblasts.
Katherine IliaNika ShakibaTrevor BinghamRoss D JonesMichael M KaminskiEliezer AraveraSimone BrunoSebastian PalaciosRon WeissJames J CollinsDomitilla Del VecchioThorsten M SchlaegerPublished in: bioRxiv : the preprint server for biology (2023)
Genetic controllers and live-cell imaging offer a versatile strategy for probing the role of transcription factor dynamics in cell fate transitions.
Keyphrases
- cell fate
- transcription factor
- genome wide
- endothelial cells
- high resolution
- copy number
- optical coherence tomography
- induced pluripotent stem cells
- molecular dynamics simulations
- single molecule
- gene expression
- dna binding
- diabetic retinopathy
- pluripotent stem cells
- mass spectrometry
- photodynamic therapy
- optic nerve