A Western diet with alcohol in drinking water recapitulates features of alcohol-associated liver disease in mice.
Michael SchonfeldMaura O'NeilMaria T VillarAntonio ArtiguesJanice AverillaSumedha GunewardenaSteven A WeinmanIrina TikhanovichPublished in: Alcoholism, clinical and experimental research (2021)
A simple-to-administer, 16-week WD alcohol model recapitulates the inflammatory, fibrotic, and gene expression aspects of human alcohol-associated steatohepatitis.
Keyphrases
- drinking water
- gene expression
- alcohol consumption
- endothelial cells
- dna methylation
- physical activity
- oxidative stress
- health risk assessment
- idiopathic pulmonary fibrosis
- type diabetes
- south africa
- randomized controlled trial
- weight loss
- risk assessment
- adipose tissue
- skeletal muscle
- heavy metals
- wild type
- placebo controlled
- liver fibrosis