Annurca apple (M. pumila Miller cv Annurca) extracts act against stress and ageing in S. cerevisiae yeast cells.
Mariarita StirpeVanessa PalermoMichele Maria BianchiRomano SilvestriClaudio FalconeGiancarlo TenoreEttore NovellinoCristina MazzoniPublished in: BMC complementary and alternative medicine (2017)
In this paper, by using the yeast S. cerevisiae as a model, we have demonstrated that Annurca extracts possess antioxidant properties thanks to which the extracts can reduce the intracellular ROS levels and have anti-apoptotic functions thus prolonging cell lifespan. These results contribute to knowledge on the effects of natural compounds on ageing and support the use of yeast as a model organism for the development of simple tests to assess the effectiveness of bioactive substances from natural sources.
Keyphrases
- saccharomyces cerevisiae
- cell death
- induced apoptosis
- cell cycle arrest
- drinking water
- randomized controlled trial
- healthcare
- cell wall
- anti inflammatory
- reactive oxygen species
- systematic review
- oxidative stress
- single cell
- dna damage
- cell therapy
- endoplasmic reticulum stress
- stress induced
- heat stress
- mesenchymal stem cells