Combined untargeted and targeted lipidomics approaches reveal potential biomarkers in type 2 diabetes mellitus cynomolgus monkeys.

Chao-Yang TianQun-Hui YangHai-Zhou LvFeng Yue Fei-Fan Zhou

Published in: Journal of medical primatology (2023)

The study found that four downregulated serum lipid species could serve as novel potential biomarkers of T2DM cynomolgus monkeys. Glycerophospholipid metabolism was filtered out as the potential therapeutic target pathway of T2DM progression. Our results showed that the identified biomarkers may offer a novel tool for tracking disease progression and response to therapeutic interventions.

Keyphrases

mass spectrometry
physical activity
type diabetes
magnetic resonance imaging
glycemic control
gene expression
metabolic syndrome
fatty acid
risk assessment
high resolution
dna methylation
computed tomography
gas chromatography mass spectrometry
image quality