Prediction of stimulus-independent and task-unrelated thought from functional brain networks.
Aaron KucyiMichael EstermanJames CapellaAllison GreenMai UchidaJoseph BiedermanJohn D E GabrieliEve M ValeraSusan Whitfield-GabrieliPublished in: Nature communications (2021)
Neural substrates of "mind wandering" have been widely reported, yet experiments have varied in their contexts and their definitions of this psychological phenomenon, limiting generalizability. We aimed to develop and test the generalizability, specificity, and clinical relevance of a functional brain network-based marker for a well-defined feature of mind wandering-stimulus-independent, task-unrelated thought (SITUT). Combining functional MRI (fMRI) with online experience sampling in healthy adults, we defined a connectome-wide model of inter-regional coupling-dominated by default-frontoparietal control subnetwork interactions-that predicted trial-by-trial SITUT fluctuations within novel individuals. Model predictions generalized in an independent sample of adults with attention-deficit/hyperactivity disorder (ADHD). In three additional resting-state fMRI studies (total n = 1115), including healthy individuals and individuals with ADHD, we demonstrated further prediction of SITUT (at modest effect sizes) defined using multiple trait-level and in-scanner measures. Our findings suggest that SITUT is represented within a common pattern of brain network interactions across time scales and contexts.
Keyphrases
- resting state
- functional connectivity
- attention deficit hyperactivity disorder
- autism spectrum disorder
- study protocol
- clinical trial
- working memory
- phase ii
- machine learning
- social media
- randomized controlled trial
- health information
- dna methylation
- cord blood
- genome wide
- gene expression
- magnetic resonance
- physical activity
- depressive symptoms
- ionic liquid
- sleep quality
- image quality