Immunohistochemical expression of CD44 in oral squamous cell carcinoma in relation to histomorphological parameters and clinicopathological factors.
Melanie BoxbergCarolin GötzSelgai HaidariChristiane DorfnerMoritz JesinghausEnken DrecollMarko BoskovKlaus D WolffWilko WeichertBernhard HallerAndreas KolkPublished in: Histopathology (2018)
Our study demonstrates the association of CD44 with tumour aggressiveness and EMT, as well as the independent prognostic impact of CD44 in a subset of OSCCs, which underlines the role of tumour cell stemness as a key factor in malignant behaviour in this disease.