Characterisation of the calcitonin gene-related peptide receptor antagonists ubrogepant and atogepant in human isolated coronary, cerebral and middle meningeal arteries.

Eloisa Rubio-BeltránKa Yi ChanAh Jan DanserAntoinette MaassenVanDenBrinkLars Edvinsson

Published in: Cephalalgia : an international journal of headache (2019)

ubrogepant and atogepant differentially inhibit the calcitonin gene-related peptide-dependent vasodilatory responses in intracranial arteries when compared to distal human coronary arteries. Also, both gepants are devoid of vasoconstrictive properties in human coronary arteries.

Keyphrases

endothelial cells
coronary artery disease
coronary artery
induced pluripotent stem cells
pluripotent stem cells
genome wide
copy number
minimally invasive
blood flow
heart failure
dna methylation
aortic stenosis
aortic valve