Comparative lipidomic analysis of inflammatory mediators in the aqueous humor and tear fluid of humans and rabbits.
Dmitry V ChistyakovNadezhda V AzbukinaAlina A AstakhovaSergei V GoriainovViktor V ChistyakovVeronika V TiulinaViktoriia E BaksheevaVladislav I KotelinElena V FedoseevaAndrey A ZamyatninPavel P PhilippovOlga A KiselevaAlexander M BessmertnyIvan I SeninElena N IomdinaMarina G SergeevaEvgeni Yu ZerniiPublished in: Metabolomics : Official journal of the Metabolomic Society (2020)
The revealed correlations confirm the feasibility of rabbit models for investigating pathogenesis and trialing therapies of human eye disorders. The identified metabolite patterns suggest enzymatic mechanisms of oxylipin generation in AH and TF and might be used as a reference in ocular inflammation studies.