Presence of autoantibodies in "seronegative" rheumatoid arthritis associates with classical risk factors and high disease activity.
Evan ReedAnna Karin HedströmMonika HanssonLinda Mathsson-AlmBoel BrynedalSaedis SaevarsdottirMartin CornilletPer-Johan JakobssonRikard HolmdahlKarl SkrinerGuy SerreLars AlfredssonJohan RönnelidKarin LundbergPublished in: Arthritis research & therapy (2020)
"Seronegative" RA is not truly a seronegative disease subset. Additional screening for ACPA fine-specificities and IgA/IgG RF defines a group of patients that resembles seropositive patients with respect to risk factors and clinical picture and may contribute to earlier diagnosis for a subset of anti-CCP2-/IgM RF- patients with a high need for active treatment.
Keyphrases
- disease activity
- rheumatoid arthritis
- risk factors
- systemic lupus erythematosus
- ankylosing spondylitis
- rheumatoid arthritis patients
- end stage renal disease
- juvenile idiopathic arthritis
- chronic kidney disease
- newly diagnosed
- ejection fraction
- interstitial lung disease
- peritoneal dialysis
- air pollution
- prognostic factors
- systemic sclerosis
- patient reported