Examining the Relationships Among Treatment, Pain, and Physical Function in Patients With Osteoarthritis: A Mediation-Modeling Approach.

Lucy AbrahamRobert H DworkinDennis C TurkJohn D MarkmanDavid A WilliamsAndrew G BushmakinJerry A HallDavid C SemelJoseph C CappelleriRuoyong Yang

Published in: The Clinical journal of pain (2023)

At least 75% of the treatment effect of tanezumab on physical functioning can be explained by the improvements in pain. However, tanezumab had an additional effect on physical functioning (~25%) that, was independent of improvements in pain. Such independent effects are of considerable interest and require further research to determine their mechanisms.

Keyphrases

chronic pain
pain management
neuropathic pain
physical activity
mental health
rheumatoid arthritis
spinal cord injury
depressive symptoms
social support
knee osteoarthritis