Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium.
Yutaka ShishikuraAkira KoaraiHiroyuki AizawaMutsuo YamayaHisatoshi SugiuraMika WatanabeYuichiro HashimotoTadahisa NumakuraTomonori MakigutiKyoko AbeMituhiro YamadaToshiaki KikuchiYasushi HoshikawaYoshinori OkadaMasakazu IchinosePublished in: Respiratory research (2016)
These results demonstrate that dsRNA induces the release of ATP via pannexin channel and that the extracellular ATP is involved in the expression and release of MUC5AC, mainly via P2Y2R, in an autocrine manner. Modulation of this pathway could be a therapeutic target for viral-induced mucus hypersecretion in COPD exacerbations.