Improving the repopulation capacity of elderly human hepatocytes by decoding aging-associated hepatocyte plasticity.

Yun-Zhong NieYun-Wen ZhengHideki Taniguchi

Published in: Hepatology (Baltimore, Md.) (2022)

This study suggests that age-induced histone hypoacetylation impairs hepatocyte plasticity, and hepatocyte plasticity might be a therapeutic target for promoting the regenerative capacity of the elderly liver.

Keyphrases

liver injury
drug induced
endothelial cells
middle aged
stem cells
high glucose
community dwelling
mesenchymal stem cells
cell therapy
gene expression
pluripotent stem cells
stress induced