Effect of mandibular advancement therapy on inflammatory and metabolic biomarkers in patients with severe obstructive sleep apnoea: a randomised controlled trial.
Sylvain RecoquillonJean Louis PépinBruno VielleRamaroson AndriantsitohainaVanessa BironneauFrédérique Chouet-GirardBernard FleuryFrançois GoupilSandrine LaunoisM Carmen MartinezNicole MeslierXuan-Lan NguyenAudrey ParisPascaline PriouRenaud TamisierWojciech TrzepizurFrédéric GagnadouxPublished in: Thorax (2018)
Systemic inflammation and metabolic disorders are among the mechanisms linking obstructive sleep apnoea (OSA) and cardiovascular disease (CVD). In 109 patients with severe OSA and no overt CVD, biomarkers of inflammation (C reactive protein, interleukin-6, tumour necrosis factor-α and its receptors, adiponectin, leptin and P-selectin), glucose and lipid metabolism, and N-terminal pro-brain natriuretic peptide, were measured before and after 2 months of treatment with a mandibular advancement device (MAD) (n=55) or a sham device (n=54). MAD reduced the Apnoea-Hypopnoea Index (p<0.001) but had no effect on circulating biomarkers compared with the sham device, despite high treatment adherence (6.6 hour/night). TRIAL REGISTRATION NUMBER: NCT01426607.
Keyphrases
- positive airway pressure
- cardiovascular disease
- obstructive sleep apnea
- oxidative stress
- sleep quality
- physical activity
- clinical trial
- early onset
- stem cells
- study protocol
- randomized controlled trial
- coronary artery disease
- combination therapy
- depressive symptoms
- replacement therapy
- drug induced
- cell therapy
- glycemic control
- cerebral ischemia
- functional connectivity