Human VDAC pseudogenes: an emerging role for VDAC1P8 pseudogene in acute myeloid leukemia.
Xena Giada PappalardoPierpaolo RisiglioneFederica ZinghirinoAngela OstuniDaniela LucianoFaustino BisacciaVito De PintoFrancesca GuarinoAngela Anna MessinaPublished in: Biological research (2023)
Our in-silico comparative analysis between the VDAC1 gene and its VDAC1P8 pseudogene, together with experimental data produced in AML cellular models, indicate a specific over-expression of the VDAC1P8 pseudogene in AML, correlated with a downregulation of the parental VDAC1 gene.
Keyphrases
- acute myeloid leukemia
- endothelial cells
- signaling pathway
- cell proliferation
- copy number
- poor prognosis
- electronic health record
- gene expression
- big data
- long non coding rna
- allogeneic hematopoietic stem cell transplantation
- dna methylation
- machine learning
- transcription factor
- acute lymphoblastic leukemia
- deep learning
- binding protein