Level of sedation in critically ill adult patients: a protocol for a systematic review with meta-analysis and trial sequential analysis.
Ameldina CericJohan HolgerssonTeresa MayMarkus B SkrifvarsJohanna HästbackaManoj SaxenaAnders AnemanAnthony DelaneyMichael Charles ReadeCandice DelcourtJanus JakobsenNiklas NielsenPublished in: BMJ open (2022)
No formal approval or review of ethics is required as individual patient data will not be included. This systematic review has the potential to highlight (1) whether one should believe sedation to be beneficial, harmful or neither in critically ill adults; (2) the existing knowledge gaps and (3) whether the recommendations from guidelines and daily clinical practice are supported by current evidence. These results will be disseminated through publication in a peer-reviewed journal.
Keyphrases
- clinical trial
- clinical practice
- systematic review
- phase ii
- phase iii
- big data
- meta analyses
- mechanical ventilation
- public health
- healthcare
- randomized controlled trial
- case report
- electronic health record
- machine learning
- risk assessment
- drug administration
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation