A novel approach to exploring the dark genome and its application to mapping of the vertebrate virus fossil record.

Daniel Blanco-MeloMatthew A CampbellHenan ZhuTristan P W DennisSejal ModhaSpyros LytrasJoseph HughesAnna GatsevaRobert James Gifford

Published in: Genome biology (2024)

We comprehensively catalog and analyze EVEs within 874 vertebrate genomes, shedding light on the distribution, diversity, and long-term evolution of viruses and reveal their extensive impact on vertebrate genome evolution. Our results demonstrate the power of linking a relational database management system to a similarity search-based screening pipeline for in silico exploration of the dark genome.

Keyphrases

genome wide
molecular docking
emergency department
single cell
gene expression
high density
molecular dynamics simulations