Relationship between Interferon Beta-1A Administration and Intracranial Vascular Tone Regulation in Patients with Relapsing-Remitting Multiple Sclerosis: A Pilot Study.
Vincenzo DattolaLilla BonannoAntonino NaroAntonino ChilluraAnna Lisa LogiudiceEdoardo SessaFausto FamàAngelo QuartaroneRocco Salvatore CalabròSilvia MarinoMargherita RussoPublished in: BioMed research international (2017)
Interferon beta (IFN-β) therapy is one of the most commonly prescribed immunomodulatory therapies in relapsing-remitting multiple sclerosis (RRMS). A reversible cerebral vasoconstriction syndrome (RCVS), associated with IFN-β use, has been recently described. For this reason, we tested the effect of once a week intramuscular administration of IFN-β-1A on the function of cerebral vessels in a cohort of RRMS patients. Using transcranial Doppler (TCD) ultrasound, we measured the mean blood flow velocity (MFV) in intracranial vessels 10 h after IFN-β administration. Measurements showed a significant increase in MFV compared to the baseline values in some vessels.
Keyphrases
- multiple sclerosis
- blood flow
- dendritic cells
- immune response
- white matter
- subarachnoid hemorrhage
- end stage renal disease
- ejection fraction
- newly diagnosed
- magnetic resonance imaging
- prognostic factors
- cerebral ischemia
- clinical trial
- cerebral blood flow
- stem cells
- optic nerve
- randomized controlled trial
- bone marrow
- case report
- patient reported outcomes
- study protocol
- smoking cessation
- placebo controlled