Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype.
Corena V GrantChase M CarverShayne D HastingsKarthik RamachandranMadesh MuniswamyApril L RisingerJohn A BeutlerSusan L MooberryPublished in: Breast cancer research and treatment (2019)
The sensitivity of BT-549 and Hs578T cells to englerin A and digoxin suggests a subset of TNBCs are highly susceptible to cation disruption and encourages investigation of TRPC1 and TRPC4 as potential new biomarkers of sensitivity to cardiac glycosides.