DNA-methylation-mediated activating of lncRNA SNHG12 promotes temozolomide resistance in glioblastoma.

Chenfei LuYutian WeiXiefeng WangZhuoran ZhangJianxing YinWentao LiLijiu ChenXiao LyuZhumei ShiWei YanYongping You

Published in: Molecular cancer (2020)

Our results suggest that SNHG12 could serve as a promising therapeutic target to surmount TMZ resistance, thereby improving the clinical efficacy of TMZ chemotherapy.

Keyphrases

dna methylation
poor prognosis
long non coding rna
signaling pathway
genome wide
locally advanced
squamous cell carcinoma
radiation therapy