• Herpud1 is upregulated in the leaflets of Hcy-treated mice and patients with CAVD. • In mice, global knockout of Herpud1 alleviates aortic valve calcification and Herpud1 silencing activates cell autophagy, inhibiting osteogenic differentiation of AVICs induced by Hcy. • 4-PBA suppressed Herpud1 expression to alleviate AVIC calcification in Hcy treated AVICs and to mitigate aortic valve calcification in mice.
Keyphrases
- aortic valve
- transcatheter aortic valve replacement
- transcatheter aortic valve implantation
- aortic valve replacement
- aortic stenosis
- chronic kidney disease
- high fat diet induced
- signaling pathway
- poor prognosis
- oxidative stress
- single cell
- type diabetes
- stem cells
- mouse model
- insulin resistance
- bone marrow
- endoplasmic reticulum stress
- adipose tissue
- replacement therapy
- cell therapy
- mesenchymal stem cells
- diabetic rats
- binding protein