Comparative efficacy and safety of antihyperglycemic drug classes for patients with type 2 diabetes following failure with metformin monotherapy: A systematic review and network meta-analysis of randomized controlled trials.

Hui ZhengRonald J SigalDoug CoyleZemin BaiAmy JohnstonJesse ElliottShuching HsiehShannon E KellyLi ChenBecky SkidmoreKarine Toupin-AprilGeorge A Wells

Published in: Diabetes/metabolism research and reviews (2022)

All eight antihyperglycemic drug classes, taken in combination with metformin, reduced HbA1c levels; however, the effects of the agents on other outcomes varied among the classes.

Keyphrases

systematic review
combination therapy
drug induced
open label
clinical trial
randomized controlled trial
electronic health record