Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer's disease and implicate its dynamic role in disease progression.

Qi WangYinghua ChenBenjamin ReadheadKewei ChenYi SuEric M ReimanJoel T Dudley

Published in: Clinical epigenetics (2020)

Our results confirm that PM20D1 is an mQTL in AD and demonstrate that it plays a dynamic role at different stages of the disease. Further in-depth study is thus warranted to fully decipher its role in the evolution of AD and potentially explore its utility as a blood-based biomarker for AD.

Keyphrases

peripheral blood
particulate matter
air pollution
heavy metals
polycyclic aromatic hydrocarbons
high resolution
gene expression
big data
machine learning
genome wide
cross sectional
water soluble
risk assessment
artificial intelligence
dna methylation
mild cognitive impairment