Generalized anxiety disorder in low-resourced adults: a nationally representative, longitudinal cohort study across the COVID-19 pandemic.

The burden of generalized anxiety disorder (GAD) accrued disproportionately over the COVID-19 pandemic to low-resource populations. Using a longitudinal, nationally representative study of U.S. adults, we used generalized estimating equations (GEE) to estimate the burden of positive screen for GAD (GAD-7 ≥10) over time. The final sample included 1270 adults ≥18 who completed the CLIMB (COVID-19 and Life Stressors Impact on Mental Health and Well-being) study, collected in Spring 2020, 2021, and 2022. The national prevalence of positive screen for GAD decreased from 24.4% in 2020 to 21.3% in 2022 (p<0.05). Across the COVID-19 pandemic, factors associated with increased odds of positive screen for GAD were: lower income (OR:2.06 [95%CI: 1.17,3.63] for ≤$19,999 relative to ≥$75,000), younger age (OR:2.55 [95% CI:1.67,3.89] for ages 18-39 relative to ≥60 years), and having contracted COVID-19 (OR:1.54 [95%CI:1.12,2.14]). Experiencing stressors was associated with 14% increased odds of positive screen for GAD for each additional stressor. The 2020 stressors most strongly associated with positive screen for GAD in 2022 were job loss and difficulties paying rent. Efforts to address the stressors affecting groups with the highest burden of anxiety post-pandemic may help to mitigate poor mental health exacerbated during the COVID-19 pandemic.