Flavan-3-ol Microbial Metabolites Modulate Proteolysis in Neuronal Cells Reducing Amyloid-beta (1-42) Levels.
Valentina CecariniMassimiliano CuccioloniYadong ZhengLaura BonfiliChunmei GongMauro AngelettiPedro MenaDaniele Del RioAnna Maria EleuteriPublished in: Molecular nutrition & food research (2021)
The findings of this study establish, for the first time, that these metabolites exert a neuroprotective activity by regulating intracellular proteolysis and confirm the role of autophagy and cathepsin B as possible targets of AD preventive/therapeutic strategies.