Interferon gamma decreases intestinal epithelial aquaporin 3 expression through downregulation of constitutive transcription.

Michael A PeplowskiMichael DicayCristiane H BaggioFilip WysokinskiBernard RenauxMorley D HollenbergDavid ProudWallace K MacNaughton

Published in: Journal of molecular medicine (Berlin, Germany) (2018)

• IFNγ suppresses the expression of AQP3 in intestinal epithelial cells. • Proximal AQP3 promoter elements are sufficient to drive constitutive expression and mediate the IFNγ-induced downregulation of AQP3 mRNA expression. • IFNγ-induced suppression of AQP3 is dependent upon STAT1 expression, but not STAT3, Sp1, or Sp3.

Keyphrases

poor prognosis
cell proliferation
dendritic cells
immune response
signaling pathway
binding protein
transcription factor
gene expression
diabetic rats
oxidative stress