Parkinson Disease and Subthalamic Nucleus Deep Brain Stimulation: Cognitive Effects in GBA Mutation Carriers.
Gian D PalGraziella MangoneEmily J HillBichun OuyangYuanqing LiuVanessa LytheDebra EhrlichRachel Saunders-PullmanVicki ShankerSusan BressmanRoy N AlcalayPriscilla GarciaKaren S MarderJan AaslyM Maral MouradianSamantha LinkMarc RosenbaumSharlet AndersonBryan BernardRobert WilsonGlenn StebbinsWilliam C NicholsMarie-Laure WelterSepehr SaniMitra AfshariLeo VerhagenRob M A de BieTom FoltynieDeborah A HallJean-Christophe CorvolChristopher G GoetzPublished in: Annals of neurology (2022)
Although not randomized, this composite analysis suggests that the combined effects of GBA mutations and STN-DBS negatively impact cognition. We advise that DBS candidates be screened for GBA mutations as part of the presurgical decision-making process. We advise that GBA mutation carriers be counseled regarding potential risks associated with STN-DBS so that alternative options may be considered. ANN NEUROL 2022;91:424-435.