Histopathological Features Predicting Long-term Clinical Outcomes in Patients with Vanishing Bile Duct Syndrome.

Tingting LvHaitian YuXiao HanAileen WeeJimin LiuMin LiJinghang XuXiaoli HuJia LiWeijia DuanTailing WangJi-Dong Jia Xin-Yan Zhao

Published in: Journal of clinical and translational hepatology (2023)

Nearly half of VBDS patients studied progressed to end-stage liver disease and 23% of them had LT or liver-related death within two years of diagnosis. Hepatocellular cholestasis, foam cells and advanced fibrosis rather than the degree of bile duct loss or underlying etiologies were independently associated with poor prognosis in VBDS patients.

Keyphrases

poor prognosis
end stage renal disease
ejection fraction
newly diagnosed
peritoneal dialysis
prognostic factors
long non coding rna
induced apoptosis
signaling pathway
patient reported
cell death