Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU.
Mette KragSøren MarkerAnders PernerJørn WetterslevMatt P WiseJoerg C SchefoldFrederik KeusAnne B GuttormsenStepani BendelMark BorthwickTheis LangeBodil S RasmussenMartin SiegemundHelle BundgaardThomas ElkmannJacob V JensenRune D NielsenLisbeth LiboriussenMorten H BestleJeanie M ElkjærDorte F PalmqvistMinna BäcklundJon H LaakePer M BådstøløkkenJuha GrönlundOlena BreumAkil WalliRobert WindingSusanne IversenInge-Lise JarnvigJonathan O WhiteBjörn BrandMartin Bruun MadsenLars QuistKlaus J ThornbergAnders MøllerJørgen WiisAnders GranholmCarl T AnthonTine S MeyhoffPeter B HjortrupSøren R AagaardJo B AndreasenChristina A SørensenPernille HaureJacob HaugeAlexa HollingerJonas ScheuzgerDaniel TuchschererThierry VuilliomenetJukka TakalaStephan M JakobMarianne L VangKim B PælestikKaren L D AndersenIwan C C van der HorstWillem DieperinkJesper FjølnerCilia K W KjerChristine SøllingChristoffer G SøllingJohanna KarttunenMatt P G MorganBrit SjøbøJanus EngstrømBirgit Agerholm-LarsenMorten H Møllernull nullPublished in: The New England journal of medicine (2018)
Among adult patients in the ICU who were at risk for gastrointestinal bleeding, mortality at 90 days and the number of clinically important events were similar in those assigned to pantoprazole and those assigned to placebo. (Funded by Innovation Fund Denmark and others; SUP-ICU ClinicalTrials.gov number, NCT02467621 .).
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