Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus.

Lina OdqvistZala JevnikarRebecca RiiseLisa ÖbergMagdalena RhedinDag LeonardLinda YrlidSonya JacksonJohan MattssonSambit NandaPhilip CohenAxel KnebelSimon ArthurKristofer ThörnElisabet SvenungssonAndreas JönsenIva GunnarssonKarolina TandreAndrei AlexssonAlf KastbomSolbritt Rantapää-DahlqvistMaija-Leena ElorantaAnn-Christine SyvänenAnders BengtssonPatrik JohanssonJohanna K SandlingChristopher SjöwallLars RönnblomBarry CollinsOuti Vaarala

Published in: Annals of the rheumatic diseases (2019)

We propose that genetic alterations disrupting the A20 DUB domain mediate increased susceptibility to SLE through the upregulation of PADI4 with resultant protein citrullination and extracellular trap formation.

Keyphrases

genome wide
copy number
cell proliferation
poor prognosis
small molecule
protein protein