Stem cell properties of human clonal salivary gland stem cells are enhanced by three-dimensional priming culture in nanofibrous microwells.

Hyun-Soo ShinSongyi LeeHye Jin HongYoung Chang LimWon-Gun KohJae-Yol Lim

Published in: Stem cell research & therapy (2018)

The 3D spheroid culture of SGSCs in nanofibrous microwells promotes stem cell properties via activation of Wnt signaling. This may contribute to SGSC priming prior to regenerative therapy to restore salivary hypofunction after radiotherapy.

Keyphrases

stem cells
endothelial cells
cell therapy
tissue engineering
early stage
radiation therapy
induced pluripotent stem cells
radiation induced
pluripotent stem cells
locally advanced
squamous cell carcinoma
mesenchymal stem cells
bone marrow