Type 2 Diabetes Mellitus and Amyotrophic Lateral Sclerosis: Genetic Overlap, Causality, and Mediation.

Haimiao ChenJinhui ZhangTing WangShuo ZhangQingwei LaiShuiping Huang Ping Zeng

Published in: The Journal of clinical endocrinology and metabolism (2021)

We provide new evidence supporting the observed inverse link between T2D and ALS, and revealed that a shared genetic component and causal association commonly drove such a relationship. We also demonstrate the mediating role of T2D standing in the pathway from T2D-related glycemic/anthropometric traits to ALS.

Keyphrases

amyotrophic lateral sclerosis
genome wide
type diabetes
glycemic control
body composition
dna methylation
single cell
social support
emergency department
adverse drug
metabolic syndrome
insulin resistance
depressive symptoms
cardiovascular risk factors
skeletal muscle
weight loss